Novel receptor-derived cyclopeptides to treat heart failure caused by anti-β1-adrenoceptor antibodies in a human-analogous rat model.

Novel receptor-derived cyclopeptides to treat heart failure caused by anti-β1-adrenoceptor antibodies in a human-analogous rat model.

Despite recent therapeutic advances the prognosis of heart failure remains poor. Recent research suggests that heart failure is a heterogeneous syndrome and that many patients have stimulating auto-antibodies directed against the second extracellular loop of the β1 adrenergic receptor (β1EC2). In a...

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Bibliographic Details
Main Authors: Valérie Boivin, Niklas Beyersdorf, Dieter Palm, Viacheslav O Nikolaev, Angela Schlipp, Justus Müller, Doris Schmidt, Vladimir Kocoski, Thomas Kerkau, Thomas Hünig, Georg Ertl, Martin J Lohse, Roland Jahns
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0117589

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https://doi.org/10.1371/journal.pone.0117589

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