Noncoding Centromeric RNA Expression Impairs Chromosome Stability in Human and Murine Stem Cells
We analyzed the effect of transcribed noncoding RNA centromeric satellites on chromosome segregation in normal human and murine stem and fibrosarcoma cells. The overexpression of different centromeric alphoid DNAs in all cell lines induced a marked increase in chromosome mis-segregation in anaphase....
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2017-01-01
|
| Series: | Disease Markers |
| Online Access: | http://dx.doi.org/10.1155/2017/7506976 |