Longitudinal study revealing motor, cognitive and behavioral decline in a transgenic minipig model of Huntington's disease

Huntington's disease (HD) is an inherited devastating neurodegenerative disease with no known cure to date. Several therapeutic treatments for HD are in development, but their safety, tolerability and efficacy need to be tested before translation to bedside. The monogenetic nature of this disor...

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Bibliographic Details
Main Authors: Monika Baxa, Bozena Levinska, Monika Skrivankova, Matous Pokorny, Jana Juhasova, Jiri Klima, Jiri Klempir, Jan Motlı́k, Stefan Juhas, Zdenka Ellederova
Format: Article
Language:English
Published: The Company of Biologists 2020-02-01
Series:Disease Models & Mechanisms
Subjects:
Online Access:http://dmm.biologists.org/content/13/2/dmm041293