Androgens predispose males to monocyte-mediated immunopathology by inducing the expression of leukocyte recruitment factor CXCL1

Androgens predispose males to monocyte-mediated immunopathology by inducing the expression of leukocyte recruitment factor CXCL1

Altered monocyte responses and testosterone levels correlate, individually, with the pathogenesis of hepatic amebiasis in mice. Here the authors show that testosterone induces enhanced TNF/CXCL1 expression and stronger proinflammatory responses in both human and mouse monocytes to support an androge...

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Bibliographic Details
Main Authors: Julie Sellau, Marie Groneberg, Helena Fehling, Thorsten Thye, Stefan Hoenow, Claudia Marggraff, Marie Weskamm, Charlotte Hansen, Stephanie Stanelle-Bertram, Svenja Kuehl, Jill Noll, Vincent Wolf, Nahla Galal Metwally, Sven Hendrik Hagen, Christoph Dorn, Julia Wernecke, Harald Ittrich, Egbert Tannich, Thomas Jacobs, Iris Bruchhaus, Marcus Altfeld, Hannelore Lotter
Format: Article
Language:English
Published: Nature Publishing Group 2020-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-17260-y

Internet

https://doi.org/10.1038/s41467-020-17260-y

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