T3 Critically Affects the Mhrt/Brg1 Axis to Regulate the Cardiac MHC Switch: Role of an Epigenetic Cross-Talk

T3 Critically Affects the Mhrt/Brg1 Axis to Regulate the Cardiac MHC Switch: Role of an Epigenetic Cross-Talk

The LncRNA my-heart (Mhrt) and the chromatin remodeler Brg1 inhibit each other to respectively prevent or favor the maladaptive α-myosin-heavy-chain (Myh6) to β-myosin-heavy-chain (Myh7) switch, so their balance crucially guides the outcome of cardiac remodeling under stress conditions. Even though...

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Bibliographic Details
Main Authors: Francesca Forini, Giuseppina Nicolini, Claudia Kusmic, Romina D’Aurizio, Alberto Mercatanti, Giorgio Iervasi, Letizia Pitto
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cells
Subjects:
long non-coding Mhrt
Brg1
chromatin remodeling
myosin heavy chain switch
low T3 state
T3 replacement
Online Access:https://www.mdpi.com/2073-4409/9/10/2155

Internet

https://www.mdpi.com/2073-4409/9/10/2155

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