Scale-Up Synthesis and Identification of GLYX-13, a NMDAR Glycine-Site Partial Agonist for the Treatment of Major Depressive Disorder

Scale-Up Synthesis and Identification of GLYX-13, a NMDAR Glycine-Site Partial Agonist for the Treatment of Major Depressive Disorder

GLYX-13, a NMDAR glycine-site partial agonist, was discovered as a promising antidepressant with rapidly acting effects but no ketamine-like side effects. However, the reported synthetic process route had deficiencies of low yield and the use of unfriendly reagents. Here, we report a scaled-up synth...

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Bibliographic Details
Main Authors: Wenchao Li, Jingjian Liu, Minghua Fan, Zhongtang Li, Yin Chen, Guisen Zhang, Zhuo Huang, Liangren Zhang
Format: Article
Language:English
Published: MDPI AG 2018-04-01
Series:Molecules
Subjects:
GLYX-13
NMDA receptor
chromatography-free synthesis
crystal structure
whole-cell voltage-clamp
Online Access:http://www.mdpi.com/1420-3049/23/5/996

Internet

http://www.mdpi.com/1420-3049/23/5/996

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