Matrix Metalloproteinase-8 Augments Bacterial Clearance in a Juvenile sepsis Model

Matrix Metalloproteinase-8 Augments Bacterial Clearance in a Juvenile sepsis Model

Abstract Genetic ablation or pharmacologic inhibition of matrix metalloproteinase-8 (MMP8) improves survival in an adult murine sepsis model. Because developmental age influences the host inflammatory response, we hypothesized that developmental age influences the role of MMP8 in sepsis. First, we c...

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Main Authors: Sarah J Atkinson, Brian M Varisco, Mary Sandquist, Meghan N Daly, Lindsey Klingbeil, Joshua W Kuethe, Emily F Midura, Kelli Harmon, Amy Opoka, Patrick Lahni, Giovanna Piraino, Paul Hake, Basilia Zingarelli, Joel E Mortensen, James L Wynn, Hector R Wong
Format: Article
Language:English
Published: BMC 2016-08-01
Series:Molecular Medicine
Online Access:http://link.springer.com/article/10.2119/molmed.2016.00058

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http://link.springer.com/article/10.2119/molmed.2016.00058

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