Toll-Like Receptor 4 Mediates Methamphetamine-Induced Neuroinflammation through Caspase-11 Signaling Pathway in Astrocytes

Toll-Like Receptor 4 Mediates Methamphetamine-Induced Neuroinflammation through Caspase-11 Signaling Pathway in Astrocytes

Methamphetamine (METH) is an amphetamine-typed stimulant drug that is increasingly being abused worldwide. Previous studies have shown that METH toxicity is systemic, especially targeting dopaminergic neurons in the central nervous system (CNS). However, the role of neuroinflammation in METH neuroto...

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Bibliographic Details
Main Authors: Si-Hao Du, Dong-Fang Qiao, Chuan-Xiang Chen, Si Chen, Chao Liu, Zhoumeng Lin, Huijun Wang, Wei-Bing Xie
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Molecular Neuroscience
Subjects:
methamphetamine
Caspase-11
Toll-like receptor 4 (TLR4)
neuroinflammation
inflammasome
astrocyte
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00409/full

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http://journal.frontiersin.org/article/10.3389/fnmol.2017.00409/full

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