The DNA helicase recql4 is required for normal osteoblast expansion and osteosarcoma formation.

The DNA helicase recql4 is required for normal osteoblast expansion and osteosarcoma formation.

RECQL4 mutations are associated with Rothmund Thomson Syndrome (RTS), RAPADILINO Syndrome and Baller-Gerold Syndrome. These patients display a range of benign skeletal abnormalities such as low bone mass. In addition, RTS patients have a highly increased incidence of osteosarcoma (OS). The role of R...

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Bibliographic Details
Main Authors: Alvin J M Ng, Mannu K Walia, Monique F Smeets, Anthony J Mutsaers, Natalie A Sims, Louise E Purton, Nicole C Walsh, T John Martin, Carl R Walkley
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-04-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4393104?pdf=render

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http://europepmc.org/articles/PMC4393104?pdf=render

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