P53-induced reduction of lipid peroxidation supports brain microvascular endothelium integrity

Dysregulation of the blood brain barrier due to oxidative stress causes neurological disorders, such as Alzheimer's and Parkinson's disease. We employed brain microvascular endothelial cells; to investigate the effects of P53 towards the lipid oxidation of the BBB. P53 reduction by LPS, si...

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Bibliographic Details
Main Authors: Mohammad S. Akhter, Mohammad A. Uddin, Khadeja-Tul Kubra, Nektarios Barabutis
Format: Article
Language:English
Published: Elsevier 2019-09-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319357111