Indoleamine 2, 3-dioxygenase Up-regulates Hypoxia-inducible Factor-1α Expression by Degrading L-tryptophan but Not Its Activity in Human Alloreactive T-cells

Indoleamine 2, 3-dioxygenase Up-regulates Hypoxia-inducible Factor-1α Expression by Degrading L-tryptophan but Not Its Activity in Human Alloreactive T-cells

Indoleamine 2, 3-dioxygenase (IDO) suppresses T-cell function at least in part by altering cell metabolism. Hypoxia-inducible factor-1 (HIF-1) increases upon T-cell activation and alters cell metabolism favoring their differentiation to effector cells. The effect of IDO on HIF-1α expression and act...

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Bibliographic Details
Main Authors: Theodoros Eleftheriadis, Georgios Pissas, Vassilios Liakopoulos, Ioannis Stefanidis
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2018-02-01
Series:Iranian Journal of Allergy, Asthma and Immunology
Subjects:
c-Myc
Hypoxia-inducible factor-1 (HIF-1) α
Indoleamine 2
3-dioxygenase
Metabolism
p53
Online Access:https://ijaai.tums.ac.ir/index.php/ijaai/article/view/1454

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https://ijaai.tums.ac.ir/index.php/ijaai/article/view/1454

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