MicroRNAs Regulated by the LPS/TLR2 Immune Axis as Bona Fide Biomarkers for Diagnosis of Acute Leptospirosis

MicroRNAs Regulated by the LPS/TLR2 Immune Axis as Bona Fide Biomarkers for Diagnosis of Acute Leptospirosis

Here, we used miRNAs that are differentially regulated by the LPS/TLR2 immune axis to devise a miRNA-based diagnosis for leptospirosis. The study established the role of the circulating stable miRNAs (miR-21-5p, miR-144-3p, and miR-let-7b-5p) as an early diagnostic marker for leptospirosis. These mi...

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Bibliographic Details
Main Authors: Charles Solomon Akino Mercy, Natarajaseenivasan Suriya Muthukumaran, Prema Velusamy, Palanisamy Bothammal, Krishnamoorthi Sumaiya, Perumal Saranya, Dianne Langford, Santhanam Shanmughapriya, Kalimuthusamy Natarajaseenivasan
Format: Article
Language:English
Published: American Society for Microbiology 2020-07-01
Series:mSphere
Subjects:
leptospirosis
lps
microrna
tlr2
biomarkers
ppi network
Online Access:https://doi.org/10.1128/mSphere.00409-20

Internet

https://doi.org/10.1128/mSphere.00409-20

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