Staphylococcus epidermidis antimicrobial delta-toxin (phenol-soluble modulin-gamma) cooperates with host antimicrobial peptides to kill group A Streptococcus.

Antimicrobial peptides play an important role in host defense against pathogens. Recently, phenol-soluble modulins (PSMs) from Staphylococcus epidermidis (S. epidermidis) were shown to interact with lipid membranes, form complexes, and exert antimicrobial activity. Based on the abundance and innocui...

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Bibliographic Details
Main Authors: Anna L Cogen, Kenshi Yamasaki, Jun Muto, Katheryn M Sanchez, Laura Crotty Alexander, Jackelyn Tanios, Yuping Lai, Judy E Kim, Victor Nizet, Richard L Gallo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2796718?pdf=render