Identification of productive and transforming anal intraepithelial neoplasia using immunohistochemical markers p16INK4a and HPV E4

Identification of productive and transforming anal intraepithelial neoplasia using immunohistochemical markers p16INK4a and HPV E4

Background: Immunohistochemical (IHC) biomarkers enable standardised, reproducible grading of anal intraepithelial neoplasia (AIN) based on progression of HPV infection from transient productive infection to complete neoplastic transformation. We investigated the expression of IHC biomarker HPV E4,...

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Bibliographic Details
Main Authors: Annemiek Leeman, David Jenkins, Elske Marra, Edyta Pirog, Miekel van de Sandt, Maarten Schim van der Loeff, John Doorbar, Folkert van Kemenade, Chris Meijer, Wim Quint
Format: Article
Language:English
Published: Elsevier 2018-06-01
Series:Papillomavirus Research
Online Access:http://www.sciencedirect.com/science/article/pii/S2405852118300661

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http://www.sciencedirect.com/science/article/pii/S2405852118300661

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