Impact of Larger Sputum Volume on Xpert® MTB/RIF Assay Detection of Mycobacterium tuberculosis in Smear-Negative Individuals with Suspected Tuberculosis

Impact of Larger Sputum Volume on Xpert® MTB/RIF Assay Detection of Mycobacterium tuberculosis in Smear-Negative Individuals with Suspected Tuberculosis

As a strategy to improve the sensitivity of nucleic acid-based testing in acid-fast bacilli (AFB) negative samples, larger volumes of sputum (5–10 mL) were tested with Xpert® MTB/RIF from 176 individuals with smear-negative sputum undergoing tuberculosis evaluation. Despite larger volumes, this stra...

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Bibliographic Details
Main Authors: Sharlaa Badal-Faesen, Cynthia Firnhaber, Michelle A. Kendall, Xingye Wu, Beatriz Grinsztejn, Rodrigo Otavio da Silva Escada, Michel Fernandez, Evelyn Hogg, Ian Sanne, Pamela Johnson, David Alland, Gerald H. Mazurek, Debra A. Benator, Anne F. Luetkemeyer, the AIDS Clinical Trials Group A5295, Tuberculosis Trials Consortium Study 34 Teams
Format: Article
Language:English
Published: MDPI AG 2017-08-01
Series:Journal of Clinical Medicine
Subjects:
larger volume sputum
Xpert MTB/RIF
smear-negative suspects
Online Access:https://www.mdpi.com/2077-0383/6/8/78

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https://www.mdpi.com/2077-0383/6/8/78

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