Methods to investigate intrathecal adaptive immunity in neurodegeneration

Abstract Background Cerebrospinal fluid (CSF) provides basic mechanical and immunological protection to the brain. Historically, analysis of CSF has focused on protein changes, yet recent studies have shed light on cellular alterations. Evidence now exists for involvement of intrathecal T cells in t...

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Bibliographic Details
Main Authors: Hamilton Oh, Olivia Leventhal, Divya Channappa, Victor W. Henderson, Tony Wyss-Coray, Benoit Lehallier, David Gate
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Molecular Neurodegeneration
Subjects:
CSF
Online Access:https://doi.org/10.1186/s13024-021-00423-w