Lung necrosis and neutrophils reflect common pathways of susceptibility to Mycobacterium tuberculosis in genetically diverse, immune-competent mice

Lung necrosis and neutrophils reflect common pathways of susceptibility to Mycobacterium tuberculosis in genetically diverse, immune-competent mice

Pulmonary tuberculosis (TB) is caused by Mycobacterium tuberculosis in susceptible humans. Here, we infected Diversity Outbred (DO) mice with ∼100 bacilli by aerosol to model responses in a highly heterogeneous population. Following infection, ‘supersusceptible’, ‘susceptible’ and ‘resistant’ phenot...

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Bibliographic Details
Main Authors: Muhammad K. K. Niazi, Nimit Dhulekar, Diane Schmidt, Samuel Major, Rachel Cooper, Claudia Abeijon, Daniel M. Gatti, Igor Kramnik, Bulent Yener, Metin Gurcan, Gillian Beamer
Format: Article
Language:English
Published: The Company of Biologists 2015-09-01
Series:Disease Models & Mechanisms
Subjects:
Tuberculosis
Mycobacterium tuberculosis
Neutrophils
Necrosis
CXCL1
CXCL2
CXCL5
Machine learning
Diversity outbred
DO
Online Access:http://dmm.biologists.org/content/8/9/1141

Internet

http://dmm.biologists.org/content/8/9/1141

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