In-line monitoring of surfactant clearance in viral vaccine downstream processing

In-line monitoring of surfactant clearance in viral vaccine downstream processing

Purpose: The goal of this study is to examine the suitability of in-line infrared measurements to monitor, in real-time, surfactant concentration in the viral vaccine drug substance during a 50KDa tangential flow filtration (TFF) process. Methods: A ReactIR™ 702L instrument was used to gather spectr...

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Bibliographic Details
Main Authors: Jessie Payne, James Cronin, Manjit Haer, Jason Krouse, William Prosperi, Katherine Drolet-Vives, Matthew Lieve, Michael Soika, Matthew Balmer, Marina Kirkitadze
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Viral vaccine
Residuals
IR
ReactIR
PAT
Clearance
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037021001021

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http://www.sciencedirect.com/science/article/pii/S2001037021001021

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