In-line monitoring of surfactant clearance in viral vaccine downstream processing
Purpose: The goal of this study is to examine the suitability of in-line infrared measurements to monitor, in real-time, surfactant concentration in the viral vaccine drug substance during a 50KDa tangential flow filtration (TFF) process. Methods: A ReactIR™ 702L instrument was used to gather spectr...
Main Authors: | Jessie Payne, James Cronin, Manjit Haer, Jason Krouse, William Prosperi, Katherine Drolet-Vives, Matthew Lieve, Michael Soika, Matthew Balmer, Marina Kirkitadze |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2021-01-01
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Series: | Computational and Structural Biotechnology Journal |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2001037021001021 |
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