Design, Synthesis and Biological Evaluation of Novel Bromophenol Derivatives Incorporating Indolin-2-One Moiety as Potential Anticancer Agents

Design, Synthesis and Biological Evaluation of Novel Bromophenol Derivatives Incorporating Indolin-2-One Moiety as Potential Anticancer Agents

A series of bromophenol derivatives containing indolin-2-one moiety were designed and evaluated that for their anticancer activities against A549, Bel7402, HepG2, HeLa and HCT116 cancer cell lines using MTT assay in vitro. Among them, seven compounds (4g–4i, 5h, 6d, 7a, 7b) showed potent activity ag...

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Bibliographic Details
Main Authors: Li-Jun Wang, Shuai-Yu Wang, Bo Jiang, Ning Wu, Xiang-Qian Li, Bao-Cheng Wang, Jiao Luo, Meng Yang, Shui-Hua Jin, Da-Yong Shi
Format: Article
Language:English
Published: MDPI AG 2015-02-01
Series:Marine Drugs
Subjects:
bromophenol
indolin-2-one
anticancer
molecular hybrid
structure–activity relationship
Online Access:http://www.mdpi.com/1660-3397/13/2/806

Internet

http://www.mdpi.com/1660-3397/13/2/806

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