SENP1-mediated deSUMOylation of USP28 regulated HIF-1α accumulation and activation during hypoxia response

SENP1-mediated deSUMOylation of USP28 regulated HIF-1α accumulation and activation during hypoxia response

Abstract Background The ubiquitin-specific protease 28 (USP28) is an oncogenic deubiquitinase, which plays a critical role in tumorigenesis via antagonizing the ubiquitination and degradation of tumor suppressor protein FBXW7-mediated oncogenic substrates. USP28 controls hypoxia-dependent angiogenes...

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Bibliographic Details
Main Authors: Shi-chun Du, Lan Zhu, Yu-xing Wang, Jie Liu, Die Zhang, Yu-lu Chen, Qing Peng, Wei Liu, Bin Liu
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Cancer Cell International
Subjects:
USP28
HIF-1α
SENP1
Hypoxia
Online Access:http://link.springer.com/article/10.1186/s12935-018-0722-9

Internet

http://link.springer.com/article/10.1186/s12935-018-0722-9

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