The severity of Osteogenesis imperfecta and type I collagen pattern in human skin as determined by nonlinear microscopy: proof of principle of a diagnostic method.

The severity of Osteogenesis imperfecta and type I collagen pattern in human skin as determined by nonlinear microscopy: proof of principle of a diagnostic method.

BACKGROUND: The confirmatory diagnosis of Osteogenesis Imperfecta (OI) requires invasive, commonly bone biopsy, time consuming and destructive methods. This paper proposes an alternative method using a combination of two-photon excitation fluorescence (TPEF) and second-harmonic generation (SHG) micr...

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Bibliographic Details
Main Authors: Javier Adur, Lilia DSouza-Li, Marcus Vinícius Pedroni, Carlos E Steiner, Vitor B Pelegati, Andre A de Thomaz, Hernandes F Carvalho, Carlos L Cesar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3711916?pdf=render

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http://europepmc.org/articles/PMC3711916?pdf=render

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