Regulation of cyclin T1 during HIV replication and latency establishment in human memory CD4 T cells

Regulation of cyclin T1 during HIV replication and latency establishment in human memory CD4 T cells

Abstract Background The regulatory cyclin, Cyclin T1 (CycT1), is a host factor essential for HIV-1 replication in CD4 T cells and macrophages. The importance of CycT1 and the Positive Transcription Elongation Factor b (P-TEFb) complex for HIV replication is well-established, but regulation of CycT1...

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Bibliographic Details
Main Authors: Jacob Couturier, Aaron F. Orozco, Hongbing Liu, Sona Budhiraja, Edward B. Siwak, Pramod N. Nehete, K. Jagannadha Sastry, Andrew P. Rice, Dorothy E. Lewis
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Virology Journal
Subjects:
Cyclin T1
Flow cytometry
HIV latency
HIV replication
HIV reservoirs
Memory CD4 T cells
Online Access:http://link.springer.com/article/10.1186/s12985-019-1128-6

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http://link.springer.com/article/10.1186/s12985-019-1128-6

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