Spreading depolarization remarkably exacerbates ischemia-induced tissue acidosis in the young and aged rat brain

Spreading depolarization remarkably exacerbates ischemia-induced tissue acidosis in the young and aged rat brain

Abstract Spreading depolarizations (SDs) occur spontaneously in the cerebral cortex of subarachnoid hemorrhage, stroke or traumatic brain injury patients. Accumulating evidence prove that SDs exacerbate focal ischemic injury by converting zones of the viable but non-functional ischemic penumbra to t...

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Bibliographic Details
Main Authors: Ákos Menyhárt, Dániel Zölei-Szénási, Tamás Puskás, Péter Makra, M. Tóth Orsolya, Borbála É. Szepes, Réka Tóth, Orsolya Ivánkovits-Kiss, Tihomir P. Obrenovitch, Ferenc Bari, Eszter Farkas
Format: Article
Language:English
Published: Nature Publishing Group 2017-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-01284-4

Internet

https://doi.org/10.1038/s41598-017-01284-4

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