Cyclophillin A deficiency accelerates RML-induced prion disease

Cyclophillin A deficiency accelerates RML-induced prion disease

Prion diseases typically involve brain deposition of abnormally folded prion protein, which is associated with activated glia and increased cytokine production. Cyclophilin A (CypA) is a ubiquitous protein with peptidyl prolyl cis-trans isomerase activity, which regulates protein folding, and can be...

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Bibliographic Details
Main Authors: Ihssane Bouybayoune, Liliana Comerio, Laura Pasetto, Ilaria Bertani, Valentina Bonetto, Roberto Chiesa
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:Neurobiology of Disease
Subjects:
Protein misfolding
Prion protein
PrP
Scrapie
PPIA
Microglia
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119301536

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http://www.sciencedirect.com/science/article/pii/S0969996119301536

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