Co-translational assembly of mammalian nuclear multisubunit complexes

Genes encoding protein complex subunits are often dispersed in the genome of eukaryotes, raising the question how these protein complexes assemble. Here, the authors provide evidence that mammalian nuclear transcription complexes are formed co-translationally to ensure specific and functional intera...

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Bibliographic Details
Main Authors: Ivanka Kamenova, Pooja Mukherjee, Sascha Conic, Florian Mueller, Farrah El-Saafin, Paul Bardot, Jean-Marie Garnier, Doulaye Dembele, Simona Capponi, H. T. Marc Timmers, Stéphane D. Vincent, László Tora
Format: Article
Language:English
Published: Nature Publishing Group 2019-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09749-y