Possible Role of PHD Inhibitors as Hypoxia-Mimicking Agents in the Maintenance of Neural Stem Cells’ Self-Renewal Properties

Possible Role of PHD Inhibitors as Hypoxia-Mimicking Agents in the Maintenance of Neural Stem Cells’ Self-Renewal Properties

Hypoxia is the most critical factor for maintaining stemness. During embryonic development, neural stem cells (NSCs) reside in hypoxic niches, and different levels of oxygen pressure and time of hypoxia exposure play important roles in the development of NSCs. Such hypoxic niches exist in adult brai...

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Bibliographic Details
Main Authors: Li-Ying Wu, Yun-Ling He, Ling-Ling Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
PHDs
inhibitors
NSCs
HIFs
hypoxia
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2018.00169/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2018.00169/full

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