Structural insights into the mechanism of RNA recognition by the N-terminal RNA-binding domain of the SARS-CoV-2 nucleocapsid phosphoprotein

Structural insights into the mechanism of RNA recognition by the N-terminal RNA-binding domain of the SARS-CoV-2 nucleocapsid phosphoprotein

The emergence of recent SARS-CoV-2 has become a global health issue. This single-stranded positive-sense RNA virus is continuously spreading with increasing morbidities and mortalities. The proteome of this virus contains four structural and sixteen nonstructural proteins that ensure the replication...

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Bibliographic Details
Main Authors: Abbas Khan, Muhammad Tahir Khan, Shoaib Saleem, Muhammad Junaid, Arif Ali, Syed Shujait Ali, Mazhar Khan, Dong-Qing Wei
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Nucleocapsid Phosphoprotein
RNA binding
Alanine scanning
PCA
DCCM
Free energy calculations
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037020303597

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http://www.sciencedirect.com/science/article/pii/S2001037020303597

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