IFITM3 polymorphism rs12252-C restricts influenza A viruses.

IFITM3 polymorphism rs12252-C restricts influenza A viruses.

The IFITM3 polymorphism rs12252-C, which encodes an IFITM3 isoform (Δ21 IFITM3) lacking 21 amino acids at the amino terminus, has been controversially associated with poor clinical outcomes in patients with H1N1 influenza A virus (IAV) infections. In vitro studies have shown that Δ21 IFITM3 loses it...

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Bibliographic Details
Main Authors: David Evan Joseph Williams, Wan-Lin Wu, Christopher Robert Grotefend, Vladimir Radic, Changik Chung, Young-Hwa Chung, Michael Farzan, I-Chueh Huang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4196997?pdf=render

Internet

http://europepmc.org/articles/PMC4196997?pdf=render

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