Soluble RAGE Treatment Delays Progression of Amyotrophic Lateral Sclerosis in SOD1 Mice

Soluble RAGE Treatment Delays Progression of Amyotrophic Lateral Sclerosis in SOD1 Mice

The etiology of amyotrophic lateral sclerosis (ALS), a fatal motor neuron disorder characterized by progressive muscle weakness and spasticity, remains largely unknown. Approximately 5-10% of cases are familial, and of those, 15-20% are associated with mutations in the gene encoding Cu/Zn superoxide...

Full description

Bibliographic Details
Main Authors: Judyta K Juranek, Gurdip K Daffu, Matthew S Geddis, Huilin eLi, Rosa eRosario, Benjamin S Kaplan, Lauren eKelly, Ann Marie eSchmidt
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Amyotrophic Lateral Sclerosis
Motor Neurons
Rage
Spinal Cord
SOD1
Soluble RAGE
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00117/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00117/full

Similar Items