Novel Heat Shock Protein 90 Inhibitors Suppress P-Glycoprotein Activity and Overcome Multidrug Resistance in Cancer Cells

Novel Heat Shock Protein 90 Inhibitors Suppress P-Glycoprotein Activity and Overcome Multidrug Resistance in Cancer Cells

Heat Shock Protein 90 (Hsp90) chaperone interacts with a broad range of client proteins involved in cancerogenesis and cancer progression. However, Hsp90 inhibitors were unsuccessful as anticancer agents due to their high toxicity, lack of selectivity against cancer cells and extrusion by membrane t...

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Bibliographic Details
Main Authors: Jelena Dinić, Ana Podolski-Renić, Mirna Jovanović, Loana Musso, Ivanka Tsakovska, Ilza Pajeva, Sabrina Dallavalle, Milica Pešić
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:International Journal of Molecular Sciences
Subjects:
isoxazolonaphthoquinones
Hsp90 inhibitors
P-glycoprotein inhibitors
cancer
multidrug resistance
Online Access:https://www.mdpi.com/1422-0067/20/18/4575

Internet

https://www.mdpi.com/1422-0067/20/18/4575

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