Secreted CLCA1 modulates TMEM16A to activate Ca2+-dependent chloride currents in human cells

Secreted CLCA1 modulates TMEM16A to activate Ca2+-dependent chloride currents in human cells

Calcium-activated chloride channel regulator 1 (CLCA1) activates calcium-dependent chloride currents; neither the target, nor mechanism, is known. We demonstrate that secreted CLCA1 activates calcium-dependent chloride currents in HEK293T cells in a paracrine fashion, and endogenous TMEM16A/Anoctami...

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Bibliographic Details
Main Authors: Monica Sala-Rabanal, Zeynep Yurtsever, Colin G Nichols, Tom J Brett
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-03-01
Series:eLife
Subjects:
ion channel regulation
calcium activated chloride channel
chronic inflammatory airway disease
Online Access:https://elifesciences.org/articles/05875

Internet

https://elifesciences.org/articles/05875

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