The F(ab′)2 fragment of an Aβ-specific monoclonal antibody reduces Aβ deposits in the brain

This work examines whether administering the F(ab´)2 fragment of an IgG1 monoclonal antibody (mAb) targeting the N-terminal 1–13 amino acids of the β-amyloid peptide (Aβ mAb) reduces amyloid deposition in Alzheimer's disease (AD). The F(ab′)2 fragment was injected intraperitoneally or intracran...

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Bibliographic Details
Main Authors:	Yuichi Tamura, Kenji Hamajima, Kiyohiko Matsui, Shunsuke Yanoma, Masato Narita, NobuyoshiI Tajima, Ke-Qin Xin, Dennis Klinman, Kenji Okuda
Format:	Article
Language:	English
Published:	Elsevier 2005-11-01
Series:	Neurobiology of Disease
Subjects:	Alzheimer's disease Tg2576 mouse β-amyloid peptide (Aβ) F(ab′)2 fragment IgG1 isotype Anti-Aβ monoclonal antibody
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996105001233

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http://www.sciencedirect.com/science/article/pii/S0969996105001233

The F(ab′)2 fragment of an Aβ-specific monoclonal antibody reduces Aβ deposits in the brain

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