The Interplay between CD27dull and CD27bright B Cells Ensures the Flexibility, Stability, and Resilience of Human B Cell Memory

The Interplay between CD27dull and CD27bright B Cells Ensures the Flexibility, Stability, and Resilience of Human B Cell Memory

Summary: Memory B cells (MBCs) epitomize the adaptation of the immune system to the environment. We identify two MBC subsets in peripheral blood, CD27dull and CD27bright MBCs, whose frequency changes with age. Heavy chain variable region (VH) usage, somatic mutation frequency replacement-to-silent r...

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Main Authors: Ola Grimsholm, Eva Piano Mortari, Alexey N. Davydov, Mikhail Shugay, Anna S. Obraztsova, Chiara Bocci, Emiliano Marasco, Valentina Marcellini, Alaitz Aranburu, Chiara Farroni, Domenico Alessandro Silvestris, Cristina Cristofoletti, Ezio Giorda, Marco Scarsella, Simona Cascioli, Sabina Barresi, Vassilios Lougaris, Alessandro Plebani, Caterina Cancrini, Andrea Finocchi, Viviana Moschese, Diletta Valentini, Cristina Vallone, Fabrizio Signore, Giovanni de Vincentiis, Salvatore Zaffina, Giandomenico Russo, Angela Gallo, Franco Locatelli, Alberto E. Tozzi, Marco Tartaglia, Dmitriy M. Chudakov, Rita Carsetti
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720301765

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http://www.sciencedirect.com/science/article/pii/S2211124720301765

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