Type I Interferon Receptor Signaling of Neurons and Astrocytes Regulates Microglia Activation during Viral Encephalitis

Type I Interferon Receptor Signaling of Neurons and Astrocytes Regulates Microglia Activation during Viral Encephalitis

Summary: In sterile neuroinflammation, a pathological role is proposed for microglia, whereas in viral encephalitis, their function is not entirely clear. Many viruses exploit the odorant system and enter the CNS via the olfactory bulb (OB). Upon intranasal vesicular stomatitis virus instillation, w...

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Main Authors: Chintan Chhatbar, Claudia N. Detje, Elena Grabski, Katharina Borst, Julia Spanier, Luca Ghita, David A. Elliott, Marta Joana Costa Jordão, Nora Mueller, James Sutton, Chittappen K. Prajeeth, Viktoria Gudi, Michael A. Klein, Marco Prinz, Frank Bradke, Martin Stangel, Ulrich Kalinke
Format: Article
Language:English
Published: Elsevier 2018-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718314189

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http://www.sciencedirect.com/science/article/pii/S2211124718314189

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