Structural and biochemical characterization of the exopolysaccharide deacetylase Agd3 required for Aspergillus fumigatus biofilm formation
The exopolysaccharide galactosaminogalactan (GAG) is an important virulence factor of the fungal pathogen Aspergillus fumigatus. Here, the authors study an A. fumigatus enzyme that deacetylates GAG in a metal-dependent manner and constitutes a founding member of a new carbohydrate esterase family.
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| Language: | English |
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Nature Publishing Group
2020-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-16144-5 |
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doaj-bc12a17a65694000bd265c5f6442da5e2021-05-16T11:12:06ZengNature Publishing GroupNature Communications2041-17232020-05-0111111310.1038/s41467-020-16144-5Structural and biochemical characterization of the exopolysaccharide deacetylase Agd3 required for Aspergillus fumigatus biofilm formationNatalie C. Bamford0François Le Mauff1Jaime C. Van Loon2Hanna Ostapska3Brendan D. Snarr4Yongzhen Zhang5Elena N. Kitova6John S. Klassen7Jeroen D. C. Codée8Donald C. Sheppard9P. Lynne Howell10Program in Molecular Medicine, The Hospital for Sick ChildrenDepartment of Microbiology and Immunology, Faculty of Medicine, McGill UniversityProgram in Molecular Medicine, The Hospital for Sick ChildrenDepartment of Microbiology and Immunology, Faculty of Medicine, McGill UniversityDepartment of Microbiology and Immunology, Faculty of Medicine, McGill UniversityLeiden Institute of Chemistry, Leiden UniversityAlberta Glycomics Centre and Department of Chemistry, University of AlbertaAlberta Glycomics Centre and Department of Chemistry, University of AlbertaLeiden Institute of Chemistry, Leiden UniversityDepartment of Microbiology and Immunology, Faculty of Medicine, McGill UniversityProgram in Molecular Medicine, The Hospital for Sick ChildrenThe exopolysaccharide galactosaminogalactan (GAG) is an important virulence factor of the fungal pathogen Aspergillus fumigatus. Here, the authors study an A. fumigatus enzyme that deacetylates GAG in a metal-dependent manner and constitutes a founding member of a new carbohydrate esterase family.https://doi.org/10.1038/s41467-020-16144-5 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Natalie C. Bamford François Le Mauff Jaime C. Van Loon Hanna Ostapska Brendan D. Snarr Yongzhen Zhang Elena N. Kitova John S. Klassen Jeroen D. C. Codée Donald C. Sheppard P. Lynne Howell |
| spellingShingle |
Natalie C. Bamford François Le Mauff Jaime C. Van Loon Hanna Ostapska Brendan D. Snarr Yongzhen Zhang Elena N. Kitova John S. Klassen Jeroen D. C. Codée Donald C. Sheppard P. Lynne Howell Structural and biochemical characterization of the exopolysaccharide deacetylase Agd3 required for Aspergillus fumigatus biofilm formation Nature Communications |
| author_facet |
Natalie C. Bamford François Le Mauff Jaime C. Van Loon Hanna Ostapska Brendan D. Snarr Yongzhen Zhang Elena N. Kitova John S. Klassen Jeroen D. C. Codée Donald C. Sheppard P. Lynne Howell |
| author_sort |
Natalie C. Bamford |
| title |
Structural and biochemical characterization of the exopolysaccharide deacetylase Agd3 required for Aspergillus fumigatus biofilm formation |
| title_short |
Structural and biochemical characterization of the exopolysaccharide deacetylase Agd3 required for Aspergillus fumigatus biofilm formation |
| title_full |
Structural and biochemical characterization of the exopolysaccharide deacetylase Agd3 required for Aspergillus fumigatus biofilm formation |
| title_fullStr |
Structural and biochemical characterization of the exopolysaccharide deacetylase Agd3 required for Aspergillus fumigatus biofilm formation |
| title_full_unstemmed |
Structural and biochemical characterization of the exopolysaccharide deacetylase Agd3 required for Aspergillus fumigatus biofilm formation |
| title_sort |
structural and biochemical characterization of the exopolysaccharide deacetylase agd3 required for aspergillus fumigatus biofilm formation |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-05-01 |
| description |
The exopolysaccharide galactosaminogalactan (GAG) is an important virulence factor of the fungal pathogen Aspergillus fumigatus. Here, the authors study an A. fumigatus enzyme that deacetylates GAG in a metal-dependent manner and constitutes a founding member of a new carbohydrate esterase family. |
| url |
https://doi.org/10.1038/s41467-020-16144-5 |
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