Biosynthesis of the Pseudomonas aeruginosa Extracellular Polysaccharides, Alginate, Pel, and Psl.

by Michael J Franklin, David E Nivens, Joel T Weadge, P Lynne Howell, P Lynne Howell
Published 2011-08-01

The Matrix Revisited: Opening Night for the Pel Polysaccharide Across Eubacterial Kingdoms

by Gregory B Whitfield, P Lynne Howell
Published 2021-02-01

Deacetylated microbial biofilm exopolysaccharides: It pays to be positive.

by Hanna Ostapska, P Lynne Howell, Donald C Sheppard
Published 2018-12-01

The molecular mechanism of the type IVa pilus motors

by Matthew McCallum, Stephanie Tammam, Ahmad Khan, Lori L. Burrows, P. Lynne Howell
Published 2017-05-01

A systematic pipeline for classifying bacterial operons reveals the evolutionary landscape of biofilm machineries.

by Cedoljub Bundalovic-Torma, Gregory B Whitfield, Lindsey S Marmont, P Lynne Howell, John Parkinson
Published 2020-04-01

Galactosaminogalactan (GAG) and its multiple roles in Aspergillus pathogenesis

by Cornelia Speth, Günter Rambach, Cornelia Lass-Flörl, P. Lynne Howell, Donald C. Sheppard
Published 2019-01-01

Multiple conformations facilitate PilT function in the type IV pilus

by Matthew McCallum, Samir Benlekbir, Sheryl Nguyen, Stephanie Tammam, John L. Rubinstein, Lori L. Burrows, P. Lynne Howell
Published 2019-11-01

Discovery and characterization of a Gram-positive Pel polysaccharide biosynthetic gene cluster.

by Gregory B Whitfield, Lindsey S Marmont, Cedoljub Bundalovic-Torma, Erum Razvi, Elyse J Roach, Cezar M Khursigara, John Parkinson, P Lynne Howell
Published 2020-04-01

The Type IVa Pilus Machinery Is Recruited to Sites of Future Cell Division

by Tyson Carter, Ryan N. C. Buensuceso, Stephanie Tammam, Ryan P. Lamers, Hanjeong Harvey, P. Lynne Howell, Lori L. Burrows, Lotte Søgaard-Andersen
Published 2017-01-01

Reducing Aspergillus fumigatus Virulence through Targeted Dysregulation of the Conidiation Pathway

by James I. P. Stewart, Vinicius M. Fava, Joshua D. Kerkaert, Adithya S. Subramanian, Fabrice N. Gravelat, Melanie Lehoux, P. Lynne Howell, Robert A. Cramer, Donald C. Sheppard
Published 2020-02-01

In vitro characterization of the antivirulence target of Gram-positive pathogens, peptidoglycan O-acetyltransferase A (OatA).

by David Sychantha, Carys S Jones, Dustin J Little, Patrick J Moynihan, Howard Robinson, Nicola F Galley, David I Roper, Christopher G Dowson, P Lynne Howell, Anthony J Clarke
Published 2017-10-01

PgaB orthologues contain a glycoside hydrolase domain that cleaves deacetylated poly-β(1,6)-N-acetylglucosamine and can disrupt bacterial biofilms.

by Dustin J Little, Roland Pfoh, François Le Mauff, Natalie C Bamford, Christina Notte, Perrin Baker, Manita Guragain, Howard Robinson, Gerald B Pier, Mark Nitz, Rajendar Deora, Donald C Sheppard, P Lynne Howell
Published 2018-04-01

Structural and biochemical characterization of the exopolysaccharide deacetylase Agd3 required for Aspergillus fumigatus biofilm formation

by Natalie C. Bamford, François Le Mauff, Jaime C. Van Loon, Hanna Ostapska, Brendan D. Snarr, Yongzhen Zhang, Elena N. Kitova, John S. Klassen, Jeroen D. C. Codée, Donald C. Sheppard, P. Lynne Howell
Published 2020-05-01

Pseudomonas aeruginosa Alginate Overproduction Promotes Coexistence with Staphylococcus aureus in a Model of Cystic Fibrosis Respiratory Infection

by Dominique H. Limoli, Gregory B. Whitfield, Tomoe Kitao, Melissa L. Ivey, Michael R. Davis, Nora Grahl, Deborah A. Hogan, Laurence G. Rahme, P. Lynne Howell, George A. O’Toole, Joanna B. Goldberg, Caroline S. Harwood
Published 2017-03-01

The role of Psl in the failure to eradicate Pseudomonas aeruginosa biofilms in children with cystic fibrosis

by Amanda J. Morris, Lindsay Jackson, Yvonne CW Yau, Courtney Reichhardt, Trevor Beaudoin, Stephanie Uwumarenogie, Kevin M. Guttman, P. Lynne Howell, Matthew R. Parsek, Lucas R. Hoffman, Dao Nguyen, Antonio DiGiandomenico, David S. Guttman, Daniel J. Wozniak, Valerie J. Waters
Published 2021-08-01

P. aeruginosa SGNH hydrolase-like proteins AlgJ and AlgX have similar topology but separate and distinct roles in alginate acetylation.

by Perrin Baker, Tyler Ricer, Patrick J Moynihan, Elena N Kitova, Marthe T C Walvoort, Dustin J Little, John C Whitney, Karen Dawson, Joel T Weadge, Howard Robinson, Dennis E Ohman, Jeroen D C Codée, John S Klassen, Anthony J Clarke, P Lynne Howell
Published 2014-08-01

Deacetylation of Fungal Exopolysaccharide Mediates Adhesion and Biofilm Formation

by Mark J. Lee, Alexander M. Geller, Natalie C. Bamford, Hong Liu, Fabrice N. Gravelat, Brendan D. Snarr, Francois Le Mauff, Joseé Chabot, Benjamin Ralph, Hanna Ostapska, Méélanie Lehoux, Robert P. Cerone, Stephanie D. Baptista, Evgeny Vinogradov, Jason E. Stajich, Scott G. Filler, P. Lynne Howell, Donald C. Sheppard
Published 2016-04-01