Introduction of synaptotagmin 7 promotes facilitation at the climbing fiber to Purkinje cell synapse

Introduction of synaptotagmin 7 promotes facilitation at the climbing fiber to Purkinje cell synapse

Summary: Synaptotagmin 7 (Syt7) is a high-affinity calcium sensor that is implicated in multiple aspects of synaptic transmission. Here, we study the influence of Syt7 on the climbing fiber (CF) to Purkinje cell (PC) synapse. We find that small facilitation and prominent calcium-dependent recovery f...

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Bibliographic Details
Main Authors: Christopher Weyrer, Josef Turecek, Bailey Harrison, Wade G. Regehr
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Cell Reports
Subjects:
synaptotagmin VII
facilitation
depression
recovery from depression
asynchronous release
probability of release
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721011682

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http://www.sciencedirect.com/science/article/pii/S2211124721011682

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