Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction

Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction

IL-36α,β and ɣ are IL-1-related cytokines promoting inflammation in the skin and intestine. Here the authors show they are elevated in individuals with obesity, and that mice lacking the IL-36 receptor antagonist are more resistant to diet-induced obesity and metabolic dysfunction, which depends on...

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Bibliographic Details
Main Authors: Eirini Giannoudaki, Yasmina E. Hernandez-Santana, Kelly Mulfaul, Sarah L. Doyle, Emily Hams, Padraic G. Fallon, Arimin Mat, Donal O’Shea, Manfred Kopf, Andrew E. Hogan, Patrick T. Walsh
Format: Article
Language:English
Published: Nature Publishing Group 2019-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11944-w

Internet

https://doi.org/10.1038/s41467-019-11944-w

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