Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction

IL-36α,β and ɣ are IL-1-related cytokines promoting inflammation in the skin and intestine. Here the authors show they are elevated in individuals with obesity, and that mice lacking the IL-36 receptor antagonist are more resistant to diet-induced obesity and metabolic dysfunction, which depends on...

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Main Authors:	Eirini Giannoudaki, Yasmina E. Hernandez-Santana, Kelly Mulfaul, Sarah L. Doyle, Emily Hams, Padraic G. Fallon, Arimin Mat, Donal O’Shea, Manfred Kopf, Andrew E. Hogan, Patrick T. Walsh
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-09-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-11944-w

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spelling	doaj-bc1452cbf30c4db3ab7be1abbb926ebf2021-05-11T11:23:45ZengNature Publishing GroupNature Communications2041-17232019-09-0110111410.1038/s41467-019-11944-wInterleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunctionEirini Giannoudaki0Yasmina E. Hernandez-Santana1Kelly Mulfaul2Sarah L. Doyle3Emily Hams4Padraic G. Fallon5Arimin Mat6Donal O’Shea7Manfred Kopf8Andrew E. Hogan9Patrick T. Walsh10Department of Clinical Medicine, School of Medicine,Trinity Translational Medicine Institute, Trinity College DublinDepartment of Clinical Medicine, School of Medicine,Trinity Translational Medicine Institute, Trinity College DublinDepartment of Clinical Medicine, School of Medicine,Trinity Translational Medicine Institute, Trinity College DublinDepartment of Clinical Medicine, School of Medicine,Trinity Translational Medicine Institute, Trinity College DublinDepartment of Clinical Medicine, School of Medicine,Trinity Translational Medicine Institute, Trinity College DublinDepartment of Clinical Medicine, School of Medicine,Trinity Translational Medicine Institute, Trinity College DublinObesity Immunology Research, St Vincent’s University Hospital and University College DublinObesity Immunology Research, St Vincent’s University Hospital and University College DublinDepartment of Biology, Molecular Biomedicine, Institute of Molecular Health Sciences, ETH ZurichNational Children’s Research Centre, Our Lady’s Children’s Hospital, CrumlinDepartment of Clinical Medicine, School of Medicine,Trinity Translational Medicine Institute, Trinity College DublinIL-36α,β and ɣ are IL-1-related cytokines promoting inflammation in the skin and intestine. Here the authors show they are elevated in individuals with obesity, and that mice lacking the IL-36 receptor antagonist are more resistant to diet-induced obesity and metabolic dysfunction, which depends on intestinal microbiota.https://doi.org/10.1038/s41467-019-11944-w
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Eirini Giannoudaki Yasmina E. Hernandez-Santana Kelly Mulfaul Sarah L. Doyle Emily Hams Padraic G. Fallon Arimin Mat Donal O’Shea Manfred Kopf Andrew E. Hogan Patrick T. Walsh
spellingShingle	Eirini Giannoudaki Yasmina E. Hernandez-Santana Kelly Mulfaul Sarah L. Doyle Emily Hams Padraic G. Fallon Arimin Mat Donal O’Shea Manfred Kopf Andrew E. Hogan Patrick T. Walsh Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction Nature Communications
author_facet	Eirini Giannoudaki Yasmina E. Hernandez-Santana Kelly Mulfaul Sarah L. Doyle Emily Hams Padraic G. Fallon Arimin Mat Donal O’Shea Manfred Kopf Andrew E. Hogan Patrick T. Walsh
author_sort	Eirini Giannoudaki
title	Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction
title_short	Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction
title_full	Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction
title_fullStr	Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction
title_full_unstemmed	Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction
title_sort	interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-09-01
description	IL-36α,β and ɣ are IL-1-related cytokines promoting inflammation in the skin and intestine. Here the authors show they are elevated in individuals with obesity, and that mice lacking the IL-36 receptor antagonist are more resistant to diet-induced obesity and metabolic dysfunction, which depends on intestinal microbiota.
url	https://doi.org/10.1038/s41467-019-11944-w
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Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction

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