CLL cells respond to B-Cell receptor stimulation with a microRNA/mRNA signature associated with MYC activation and cell cycle progression.

CLL cells respond to B-Cell receptor stimulation with a microRNA/mRNA signature associated with MYC activation and cell cycle progression.

Chronic lymphocytic leukemia (CLL) is a disease with variable clinical outcome. Several prognostic factors such as the immunoglobulin heavy chain variable genes (IGHV) mutation status are linked to the B-cell receptor (BCR) complex, supporting a role for triggering the BCR in vivo in the pathogenesi...

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Main Authors: Valerie Pede, Ans Rombout, Jolien Vermeire, Evelien Naessens, Pieter Mestdagh, Nore Robberecht, Hanne Vanderstraeten, Nadine Van Roy, Jo Vandesompele, Frank Speleman, Jan Philippé, Bruno Verhasselt
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3613353?pdf=render

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http://europepmc.org/articles/PMC3613353?pdf=render

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