Dermal fibroblasts and triple-negative mammary epithelial cancer cells differentially stiffen their local matrix

The bulk measurement of extracellular matrix (ECM) stiffness is commonly used in mechanobiology. However, past studies by our group show that peri-cellular stiffness is quite heterogeneous and divergent from the bulk. We use optical tweezers active microrheology (AMR) to quantify how two phenotypica...

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Bibliographic Details
Main Authors: Alicja Jagiełło, Micah Lim, Elliot Botvinick
Format: Article
Language:English
Published: AIP Publishing LLC 2020-12-01
Series:APL Bioengineering
Online Access:http://dx.doi.org/10.1063/5.0021030