Genome-wide analysis reveals the association between alternative splicing and DNA methylation across human solid tumors

Genome-wide analysis reveals the association between alternative splicing and DNA methylation across human solid tumors

Abstract Background Dysregulation of alternative splicing (AS) is a critical signature of cancer. However, the regulatory mechanisms of cancer-specific AS events, especially the impact of DNA methylation, are poorly understood. Methods By using The Cancer Genome Atlas (TCGA) SpliceSeq and TCGA data...

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Bibliographic Details
Main Authors: Xiaohui Sun, Yiping Tian, Jianming Wang, Zeyuan Sun, Yimin Zhu
Format: Article
Language:English
Published: BMC 2020-01-01
Series:BMC Medical Genomics
Subjects:
Alternative splicing
DNA methylation
Exon boundaries
Cancers
Association
Online Access:https://doi.org/10.1186/s12920-019-0654-9

Internet

https://doi.org/10.1186/s12920-019-0654-9

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