Hepatic overexpression of sterol carrier protein-2 inhibits VLDL production and reciprocally enhances biliary lipid secretion

Hepatic overexpression of sterol carrier protein-2 inhibits VLDL production and reciprocally enhances biliary lipid secretion

We examined in vivo a role for sterol carrier protein-2 (SCP-2) in the regulation of lipid secretion across the hepatic sinusoidal and canalicular membranes. Recombinant adenovirus Ad.rSCP2 was used to overexpress SCP-2 in livers of mice. We determined plasma, hepatic, and biliary lipid concentratio...

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Bibliographic Details
Main Authors: Ludwig Amigo, Silvana Zanlungo, Juan Francisco Miquel, Jane M. Glick, Hideyuki Hyogo, David E. Cohen, Attilio Rigotti, Flavio Nervi
Format: Article
Language:English
Published: Elsevier 2003-02-01
Series:Journal of Lipid Research
Subjects:
hepatic lipid metabolism
bile
SCP-2
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752031227X

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http://www.sciencedirect.com/science/article/pii/S002222752031227X

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