Tumor Necrosis Factor-α Induces cFOS and Strongly Potentiates Glutamate-Mediated Cell Death in the Rat Spinal Cord
Excitotoxic cell death due to glutamate release is important in the secondary injury following CNS trauma or ischemia. Proinflammatory cytokines also play a role. Both glutamate and tumor necrosis factor-α (TNFα) are released immediately after spinal cord injury. Neurophysiological studies show that...
Main Authors: | , , , |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2001-08-01
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Series: | Neurobiology of Disease |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996101904140 |