Tumor Necrosis Factor-α Induces cFOS and Strongly Potentiates Glutamate-Mediated Cell Death in the Rat Spinal Cord

Tumor Necrosis Factor-α Induces cFOS and Strongly Potentiates Glutamate-Mediated Cell Death in the Rat Spinal Cord

Excitotoxic cell death due to glutamate release is important in the secondary injury following CNS trauma or ischemia. Proinflammatory cytokines also play a role. Both glutamate and tumor necrosis factor-α (TNFα) are released immediately after spinal cord injury. Neurophysiological studies show that...

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Bibliographic Details
Main Authors: Gerlinda E. Hermann, Richard C. Rogers, Jacqueline C. Bresnahan, Michael S. Beattie
Format: Article
Language:English
Published: Elsevier 2001-08-01
Series:Neurobiology of Disease
Subjects:
spinal cord injury
cytokines
glutamate
cFOS
excitotoxic cell death
microglia
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996101904140

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http://www.sciencedirect.com/science/article/pii/S0969996101904140

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