Endogenous and Exogenous Thioredoxin 1 Prevents Goblet Cell Hyperplasia in a Chronic Antigen Exposure Asthma Model

Endogenous and Exogenous Thioredoxin 1 Prevents Goblet Cell Hyperplasia in a Chronic Antigen Exposure Asthma Model

Background: Goblet cell hyperplasia with mucus hypersecretion contribute to increased morbidity and mortality in bronchial asthma. We have reported that thioredoxin 1 (TRX1), a redox (reduction/oxidation)-active protein acting as a strong antioxidant, inhibits pulmonary eosinophilic inflammation and...

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Bibliographic Details
Main Authors: Haruki Imaoka, Tomoaki Hoshino, Masaki Okamoto, Yuki Sakazaki, Masanori Sawada, Satoko Takei, Takashi Kinoshita, Tomotaka Kawayama, Seiya Kato, Hisamichi Aizawa
Format: Article
Language:English
Published: Elsevier 2009-01-01
Series:Allergology International
Subjects:
airway remodeling
asthma
goblet cell
thioredoxin
Online Access:http://www.sciencedirect.com/science/article/pii/S1323893015307231

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http://www.sciencedirect.com/science/article/pii/S1323893015307231

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