Profiling of Histone Modifications Reveals Epigenomic Dynamics During Abdominal Aortic Aneurysm Formation in Mouse Models

Profiling of Histone Modifications Reveals Epigenomic Dynamics During Abdominal Aortic Aneurysm Formation in Mouse Models

Introduction: Abdominal aortic aneurysms (AAA) are characterized by localized inflammation, extracellular matrix degradation, and apoptosis of smooth muscle cells, which together lead to progressive and irreversible aortic dilation. Major risk factors for AAA include smoking and aging, both of which...

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Bibliographic Details
Main Authors: Jacob Greenway, Nicole Gilreath, Sagar Patel, Tetsuo Horimatsu, Mary Moses, David Kim, Lauren Reid, Mourad Ogbi, Yang Shi, Xin-Yun Lu, Mrinal Shukla, Richard Lee, Yuqing Huo, Lufei Young, Ha Won Kim, Neal L. Weintraub
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
abdominal aortic aneurysm
angiotensin II
calcium chloride
histone modification
methylation
acetylation
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2020.595011/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2020.595011/full

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