Proteomics of the corpus callosum to identify novel factors involved in hypomyelinated Niemann-Pick Type C disease mice

Proteomics of the corpus callosum to identify novel factors involved in hypomyelinated Niemann-Pick Type C disease mice

Abstract Hypomyelination in the central nerves system (CNS) is one of the most obviously pathological features in Niemann-Pick Type C disease (NPC), which is a rare neurodegenerative disorder caused by mutations in the NPC intracellular cholesterol transporter 1 or 2 (Npc1 or Npc2). Npc1 plays key r...

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Bibliographic Details
Main Authors: Fan Yang, Yudong Guan, Xiao Feng, Arndt Rolfs, Hartmut Schlüter, Jiankai Luo
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Molecular Brain
Subjects:
Proteomics
Corpus callosum
Npc1
Myelination
Lipid transport
Gltp
Online Access:http://link.springer.com/article/10.1186/s13041-019-0440-9

Internet

http://link.springer.com/article/10.1186/s13041-019-0440-9

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