Venlafaxine Improves the Cognitive Impairment and Depression-Like Behaviors in a Cuprizone Mouse Model by Alleviating Demyelination and Neuroinflammation in the Brain

Venlafaxine Improves the Cognitive Impairment and Depression-Like Behaviors in a Cuprizone Mouse Model by Alleviating Demyelination and Neuroinflammation in the Brain

Growing evidence has implicated that myelin deficits and neuroinflammation are the coexisted pathological features that contribute to the mood swing and cognitive decline in major depressive disorder (MDD) and multiple sclerosis (MS). Therefore, attenuation of neuroinflammation and reduction of demy...

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Bibliographic Details
Main Authors: Yanbo Zhang, Xiaoying Bi, Olubunmi Adebiyi, Junhui Wang, Ali Mooshekhian, Jacob Cohen, Zelan Wei, Fei Wang, Xin-Min Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Pharmacology
Subjects:
venlafaxine
cuprizone
demyelination
cognition
major depressive disorder
oligodendrocyte
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00332/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00332/full

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