Distinct white matter microstructural abnormalities and extracellular water increases relate to cognitive impairment in Alzheimer’s disease with and without cerebrovascular disease

Distinct white matter microstructural abnormalities and extracellular water increases relate to cognitive impairment in Alzheimer’s disease with and without cerebrovascular disease

Abstract Background Mixed vascular and neurodegenerative dementia, such as Alzheimer’s disease (AD) with concomitant cerebrovascular disease, has emerged as the leading cause of age-related cognitive impairment. The brain white matter (WM) microstructural changes in neurodegeneration well-documented...

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Bibliographic Details
Main Authors: Fang Ji, Ofer Pasternak, Siwei Liu, Yng Miin Loke, Boon Linn Choo, Saima Hilal, Xin Xu, Mohammad Kamran Ikram, Narayanaswamy Venketasubramanian, Christopher Li-Hsian Chen, Juan Zhou
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
Cerebrovascular disease
Diffusion tensor imaging
Free water imaging
Extracellular water
Vascular damage
Online Access:http://link.springer.com/article/10.1186/s13195-017-0292-4

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http://link.springer.com/article/10.1186/s13195-017-0292-4

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